Studii despre siguranța vaccinurilor – ROR în special.
Academia Americană de Pediatrie pune la dispoziția publicului o serie de studii care arată siguranța vaccinului ROR
Increasing exposure to antibodystimulating proteins and polysaccharides in vaccines is not associated with risk of autism
DeStefano F, Price CS, Weintraub ES. Journal of Pediatrics. 2013; http://jpeds.com/webfiles/images/journals/ympd/JPEDSDeStefano.pdf
This case-control study of more than 1,000 children compared the total exposure of antibody-stimulating proteins and polysaccharides in children with autism spectrum disorder (ASD), autistic disorder (AD), or ASD with regression to the total exposure in children who were not diagnosed with any form of autism. The children included in the study were aged 6- 13 years, but authors studied their exposures from vaccines during the first 2 years of life. Results showed that the odds of developing any of the three forms of autism studied did not rise with increased exposure to antibody-stimulating proteins and polysaccharides.
The authors concluded that parents’ concern that “too many vaccines too soon” could lead to autism is not supported. There was no indication that children with autism were more likely to have been exposed to more antigens through vaccines either in a single doctor’s visit, in the first 3 months of life, the first 7 months of life, or the first 2 years of life than were children without any diagnosis of ASD, AD or ASD with regression. The authors also pointed out that while children today may receive more vaccines than the children in this study, some of the children in this study were exposed to far more antigens (by thousands) than children today. This is because whole-cell pertussis vaccine is no longer used.
On-time Vaccine Receipt in the First Year Does Not Adversely Affect Neuropsychological Outcomes
Smith M and Woods C, Pediatrics. 2010; 125(6): 1134-41 http://pediatrics.aappublications.org/cgi/content/abstract/125/6/1134
The study of more than 1,000 children born between 1993 and 1997 looked at their vaccination schedules up to 1 year of age, and studied their performance 7 to 10 years later on 42 different neuropsychological outcomes. Timely vaccination was associated with better performance on numerous outcomes. The less-vaccinated children did not do significantly better on any of the outcomes
This comparison of children vaccinated on time with children whose vaccinations were delayed or incomplete found no benefit in delaying immunizations during the first year of life. For parents who are concerned that children receive too many vaccines too soon, these data may provide reassurance that timely vaccination during infancy has no adverse effect on long-term neuro-psychological outcomes.
Evaluation of Immunization Rates and Safety Among Children With Inborn Errors of Metabolism
Klein N, et al., Pediatrics. 2011; 127(5), e1139-46 http://pediatrics.aappublications.org/content/127/5/e1139
Researchers studied children in Northern California to determine whether 77 infants with inborn errors of metabolism who received vaccines were more likely to experience adverse events following vaccination, than 1540 matched controls (infants born without inborn errors of metabolism). Authors did not find any association between vaccination of children with inborn errors of metabolism and an increase in hospitalizations or emergency department visits within 30 days of vaccination.
On-time receipt of vaccines is not associated with increased risk for serious adverse events in the 30 days after vaccination, even in children who have metabolism conditions. This should provide reassurance that children with inborn errors of metabolism who are vaccinated routinely do not experience adverse effects
Evaluation of Immunization Rates and Safety Among Children With Inborn Errors of Metabolism
Klein N, et al., Pediatrics. 2011; 127(5), e1139-46
Researchers studied children in Northern California to determine whether 77 infants with inborn errors of metabolism who received vaccines were more likely to experience adverse events following vaccination, than 1540 matched controls (infants born without inborn errors of metabolism). Authors did not find any association between vaccination of children with inborn errors of metabolism and an increase in hospitalizations or emergencydepartment visits within 30 days of vaccination
On-time receipt of vaccines is not associated with increased risk for serious adverse events in the 30 days after vaccination, even in children who have metabolism conditions. This should provide reassurance that children with inborn errors of metabolism who are vaccinated routinely do not experience adverse effects.
Measles-Containing Vaccines and Febrile Seizures in Children Age 4 to 6 Years
Klein N, et al., Pediatrics. 2011; 129(5): 809-14
Researchers chose to perform cohort study and included 715,484 children aged 48-83 months of age who received a dose of MMRV, a dose of MMR on the same day as a dose of Varicella injected separately, or MMR alone or Varicella alone to determine the risk of post-vaccination seizure in these groups. Results showed that more fevers and seizures did occur in children who had received the MMRV vaccine, compared with children who had received MMR + Varicella, or MMR or Varicella separately, though this finding was not statistically significant. The study did not find any peak in seizure or fever activity in any of the study groups in the 7-10 post-vaccination period. Of the 4 febrile seizures observed in the 7-10 days in the post-vaccination period for children receiving MMRV, only one febrile seizure could be confirmed, resulting in authors claiming the rate of febrile seizure after MMRV to be 1 in 86,750 doses.
Overall researchers found no increased risk of febrile seizures in any of the study groups within 6 weeks of vaccination.
No Evidence for Measles, Mumps, and Rubella Vaccine-Associated Inflammatory Bowel Disease or Autism in a 14-year Prospective Study
Peltola H, et al., Lancet. 1998; 351:1327- 8 http://www.freenetpages.co.uk/hp/gingernut/lancet/Finland%20May%201998.pdf
Prospective study of 3 million adverse events in temporal relation to MMR vaccine. A form was filled and posted to the data collectors, followed by another form with further information 2-3 weeks later. Researchers traced subjects who developed gastrointestinal symptoms or signs lasting 24 hours or more at any time after MMR vaccination (apart from within the first hour). Researchers also checked hospital and health center records or interviewed the local public-health nurses.
Over a decade’s effort to detect all severe adverse events associated with MMR vaccine could find no data supporting the hypothesis that it would cause pervasive developmental disorder or inflammatory bowel disease
Autism and Measles, Mumps, and Rubella Vaccine: No Epidemiological Evidence for a Causal Association
Taylor B, et al., Lancet. 1999; 353(9169): 2026-9 http://tinyurl.com/5bgvwg
Researchers looked for a change in trend in incidence or age at diagnosis associated with the introduction of measles, mumps and rubella (MMR) vaccination to the United Kingdom in 1988. The study identified 498 cases of autism (261 of core autism, 166 of atypical autism, and 71 of Asperger syndrome) in children born in the UK since 1979. There was a steady increase in cases by year of birth with no sudden “step-up” or change in the trend line after the introduction of MMR vaccination. There was no difference in age at diagnosis between the cases vaccinated before or after 18 months of age and those never vaccinated. There was no temporal association between onset of autism within 1 or 2 years after vaccination with MMR. Developmental regression was not clustered in the months after vaccination.
Data do not support a causal association between MMR vaccine and autism. If such an association occurs, it is so rare that it could not be identified in this large regional sample.
Mumps, Measles, and Rubella Vaccine and the Incidence of Autism Recorded by General Practitioners: A Time Trend Analysis
Kaye JA, et al., British Medical Journal. 2001; 322:460-63
Study compared prevalence of measles, mumps and rubella (MMR) vaccination among children in the United Kingdom to rising prevalence of autism diagnoses for children
The data provide evidence that no correlation exists between the prevalence of MMR vaccination and the rapid increase in the risk of autism over time.
MMR and autism: further evidence against a causal association
Farrington CP, et al., Vaccine. 2001; Jun 14; 19(27): 3632-5
Data from an earlier measles, mumps and rubella (MMR) vaccine study (Taylor et al, 2000) were reanalyzed to test a second hypothesis.
Results provide further evidence against a causal association between MMR vaccination and autism.
Time Trends in Autism and in MMR Immunization Coverage in California Dales L et al., Journal of the American Medical Association. 2001; 285(9): 1183- 5 http://jama.amaassn.org/cgi/content/abstract/285/9/1183
Scientists looked for correlation between increases in the rate of autism diagnoses and increases in the rate of measles, mumps and rubella (MMR) vaccination in children born between 1980 and 1994.
These data do not suggest an immunization among young children and an increase in autism occurrence
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